Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774100 | 0.90 | NOS3 (0.42) | PDE5ANOS3NOS1NOS2POLB | |
| SCHEMBL14303430 | 0.89 | PDE5A (0.40) | PDE5ANOS3NOS1NOS2POLB | |
| SCHEMBL4778365 | 0.89 | PDE5A (0.40) | PDE5ANOS3NOS1NOS2POLB | |
| SCHEMBL4778323 | 0.88 | NOS3 (0.43) | PDE5ANOS3NOS1NOS2MEN1 | |
| SCHEMBL4776170 | 0.84 | CYP19A1 (0.39) | PDE5ANOS3NOS1NOS2MEN1 | |
| SCHEMBL4780429 | 0.83 | MOK (0.42) | MEN1ALDH1A1HPGDKMT2AADORA1 | |
| SCHEMBL4796379 | 0.82 | PDE5A (0.38) | PDE5ANOS3NOS1NOS2ALDH1A1 | |
| SCHEMBL4780443 | 0.82 | PDE5A (0.38) | PDE5ANOS3NOS1NOS2ALDH1A1 | |
| SCHEMBL4776487 | 0.82 | PDE5A (0.38) | PDE5ANOS3NOS1NOS2ALDH1A1 | |
| SCHEMBL4794991 | 0.81 | ADRA1D (0.43) | CASP3MEN1ALDH1A1KMT2AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |