Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775200 | 0.92 | L3MBTL1 (0.47) | PPARAPPARGSMN1; SMN2NPSR1CA2 | |
| SCHEMBL4777500 | 0.91 | EPHX2 (0.45) | PPARAPPARGEPHX2NR1H4SMN1; SMN2 | |
| SCHEMBL4776480 | 0.91 | PPARG (0.44) | PPARAPPARGEPHX2NR1H4SMN1; SMN2 | |
| SCHEMBL4771091 | 0.89 | EPHX2 (0.43) | PPARAPPARGEPHX2NR1H4SMN1; SMN2 | |
| SCHEMBL4773551 | 0.89 | PPARA (0.45) | PPARAPPARGEPHX2NR1H4SMN1; SMN2 | |
| SCHEMBL4773543 | 0.88 | EPHX2 (0.42) | PPARAPPARGEPHX2NR1H4SMN1; SMN2 | |
| SCHEMBL4773523 | 0.87 | EPHX2 (0.41) | PPARAPPARGEPHX2NR1H4SMN1; SMN2 | |
| SCHEMBL5571827 | 0.85 | ALDH1A1 (0.46) | PPARAPPARGEPHX2NR1H4MEN1 | |
| SCHEMBL4776821 | 0.84 | L3MBTL1 (0.43) | EPHX2NR1H4CA2CA1MEN1 | |
| SCHEMBL4777461 | 0.84 | TSHR (0.55) | SMN1; SMN2MEN1KMT2AHDAC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135435-A1 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INCORPORATED | 2007-06-14 | — | — | US | claimed |
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| US-20070135435-A1 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INCORPORATED | 2007-06-14 | — | — | US | disclosed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135435-A1 | Certain chemical entities, compositions, and methods | KIF5B, KIF2C, PLK1 | PPARA 2973/4885PPARG 2756/4885EPHX2 2831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.