Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.39 |
| ▸ | PTGES | O14684 | 4/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | DCAF1 | Q9Y4B6 | 5/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 5/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | F9 | P00740 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | XBP1 | P17861 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776562 | 0.76 | MMP2 (0.42) | MAPT | |
| SCHEMBL4776784 | 0.76 | C5AR1 (0.37) | ALOX5PPARGF9MAPTKMT2A | |
| SCHEMBL4778137 | 0.71 | ALDH1A1 (0.48) | LTB4RMAPTKMT2A | |
| SCHEMBL4780655 | 0.63 | ALDH1A1 (0.46) | ALOX5PTGESMAPTKMT2A | |
| SCHEMBL14303803 | 0.63 | MAPT (0.46) | MAPTKMT2A | |
| SCHEMBL4781742 | 0.62 | MMP2 (0.45) | MAPTKMT2A | |
| SCHEMBL4778494 | 0.62 | MMP2 (0.45) | MAPTKMT2A | |
| SCHEMBL14302669 | 0.62 | BRAF (0.47) | F10 | |
| SCHEMBL11400562 | 0.60 | ITGB3 (0.58) | ITGB3ITGA2B | |
| SCHEMBL28185336 | 0.58 | LMNA (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |