Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE9A | O76083 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4773204 | 0.88 | CHEK2 (0.38) | PDE10ADHODHPDE2APDE4B | |
| SCHEMBL4774185 | 0.78 | FFAR4 (0.32) | PDE10ADHODHPDE2APDE4B | |
| SCHEMBL4779864 | 0.76 | NOX1 (0.41) | PDE10APDE9AMEN1KMT2AKDM4E | |
| SCHEMBL4776292 | 0.70 | PDE10A (0.38) | PDE10APDE9AADORA1ADORA2AUSP2 | |
| SCHEMBL4778982 | 0.69 | PSEN1 (0.36) | MEN1KMT2AKDM4EGLAMAPT | |
| SCHEMBL4879715 | 0.69 | PIM1 (0.44) | MEN1KMT2AKDM4EGLA | |
| SCHEMBL4775583 | 0.68 | PDE10A (0.35) | PDE10AMEN1KMT2AKDM4EMAPT | |
| SCHEMBL4777353 | 0.67 | MAOA (0.37) | PDE10AADORA1ADORA2AMEN1USP2 | |
| SCHEMBL10097345 | 0.66 | MAOA (0.50) | ADORA1MEN1USP2KMT2AKDM4E | |
| SCHEMBL4771469 | 0.65 | TLR9 (0.33) | MEN1USP2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979315-A2 | METHODS FOR TREATING HEPATITIS C | PTC Therapeutics, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007084435-A2 | METHODS FOR TREATING HEPATITIS C | PTC THERAPEUTICS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |