Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PSD | A5PKW4 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774559 | 0.88 | KMT2A (0.48) | KMT2AATMSIGMAR1ALDH1A1CYP2C19 | |
| SCHEMBL4774593 | 0.85 | ALDH1A1 (0.44) | KMT2ASIGMAR1ALDH1A1CYP2C19MAPT | |
| SCHEMBL4779650 | 0.75 | MAPT (0.46) | KMT2ASIGMAR1ALDH1A1MAPTPSD | |
| SCHEMBL4778477 | 0.74 | MEN1 (0.45) | KMT2ASIGMAR1ALDH1A1MAPTHTT | |
| SCHEMBL4781142 | 0.73 | ALDH1A1 (0.48) | KMT2ASIGMAR1ALDH1A1MAPTHTT | |
| SCHEMBL4795522 | 0.72 | PIK3CA (0.53) | ATMSIGMAR1ALDH1A1MAPTHTT | |
| SCHEMBL4774611 | 0.70 | LTB4R (0.47) | KMT2AKCNH2ALDH1A1MAPTPSD | |
| SCHEMBL4816380 | 0.69 | KMT2A (0.64) | KMT2AATMADRB1ALDH1A1CYP2C19 | |
| SCHEMBL4776218 | 0.69 | CYP19A1 (0.42) | KMT2AALDH1A1MAPTPSD | |
| SCHEMBL4779144 | 0.69 | MEN1 (0.47) | KMT2AATMALDH1A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |