Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 2/20 | 0.50 |
| ▸ | EDNRA | P25101 | 2/20 | 0.50 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 3/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781223 | 0.85 | EDNRB (0.48) | EDNRBEDNRASLC40A1PGRPKM | |
| SCHEMBL4727594 | 0.85 | PIK3CG (0.41) | EDNRAPGRFBP1PIK3CDPIK3CB | |
| SCHEMBL3089179 | 0.81 | SLC40A1 (0.46) | EDNRBEDNRASLC40A1PGRWDR5 | |
| SCHEMBL4836640 | 0.74 | EDNRA (0.46) | EDNRBEDNRASLC40A1PIK3CDPIK3CB | |
| SCHEMBL4793957 | 0.72 | AGTR1 (0.47) | PKMMAPT | |
| SCHEMBL4780300 | 0.71 | ALDH1A1 (0.51) | EDNRAPKMPIK3CDPIK3CGTP53 | |
| SCHEMBL4781870 | 0.71 | PIK3CG (0.40) | EDNRBEDNRAPIK3CDPIK3CBMTOR | |
| SCHEMBL30304724 | 0.71 | AXL (0.47) | SLC40A1ACLYMAPT | |
| SCHEMBL4780564 | 0.71 | AXL (0.47) | SLC40A1ACLYMAPT | |
| SCHEMBL4726823 | 0.70 | MEN1 (0.55) | SLC40A1PGRACLYCCR2PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |