Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CCR9 | P51686 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781526 | 0.92 | MEN1 (0.48) | KMT2AMEN1PABPC1SLC22A12SCN9A | |
| SCHEMBL4782048 | 0.86 | PGR (0.54) | KMT2AKDM1ASCN9ALMNAALDH1A1 | |
| SCHEMBL4781517 | 0.85 | MEN1 (0.41) | KMT2AMEN1PABPC1SLC22A12SCN9A | |
| SCHEMBL3095654 | 0.83 | STAT3 (0.51) | KMT2AMEN1SCN9ALMNATSHR | |
| SCHEMBL4727568 | 0.81 | GFER (0.43) | KMT2AMEN1PABPC1SLC22A12SCN9A | |
| SCHEMBL4781379 | 0.81 | TSHR (0.46) | KMT2AMEN1SLC22A12SCN9ALMNA | |
| SCHEMBL4779284 | 0.80 | AXL (0.51) | KMT2AMEN1SCN9ALMNATSHR | |
| SCHEMBL13146426 | 0.79 | CCR2 (0.52) | SCN9A | |
| SCHEMBL4781354 | 0.79 | BRAF (0.42) | KMT2AMEN1PABPC1SLC22A12CCR9 | |
| SCHEMBL3083474 | 0.76 | DNMT1 (0.46) | KMT2AMEN1LMNAALDH1A1CCR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |