Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CCR9 | P51686 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
| ▸ | CCR4 | P51679 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4778484 | 0.86 | KMT2A (0.48) | SCN9AKDM1AALDH1A1PKMKMT2A | |
| SCHEMBL4779284 | 0.85 | AXL (0.51) | PGRSCN9ASLC40A1GLO1GAA | |
| SCHEMBL4781817 | 0.84 | SLC40A1 (0.48) | PGRSCN9ASLC40A1CCR4 | |
| SCHEMBL3098833 | 0.84 | SLC40A1 (0.55) | PGRSCN9AKDM1ASLC40A1ALDH1A1 | |
| SCHEMBL4777634 | 0.80 | SLC40A1 (0.47) | PGRSCN9AKDM1AMAOASLC40A1 | |
| SCHEMBL18315257 | 0.80 | KEAP1 (0.50) | PGRSLC40A1GLO1KMT2ACCR9 | |
| SCHEMBL30304671 | 0.80 | KEAP1 (0.50) | PGRSLC40A1GLO1KMT2ACCR9 | |
| SCHEMBL3098055 | 0.80 | AXL (0.52) | PGRSCN9ASLC40A1GLO1GAA | |
| SCHEMBL3095682 | 0.78 | PIK3C2B (0.36) | PGRSCN9AKDM1AMAOAALDH1A1 | |
| SCHEMBL4781526 | 0.78 | MEN1 (0.48) | SCN9AALDH1A1PKMKMT2ACCR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |