Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.46 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.46 |
| ▸ | SLC25A1 | P53007 | 1/20 | 0.46 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.45 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.45 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.45 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | CCR9 | P51686 | 1/20 | 0.43 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780415 | 0.84 | MEN1 (0.57) | MAPTALDH1A1LMNAL3MBTL1MEN1 | |
| SCHEMBL4781526 | 0.84 | MEN1 (0.48) | MAPTCCR9ALDH1A1LMNAHTT | |
| SCHEMBL4777554 | 0.81 | PKM (0.46) | CCR9SMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL3095654 | 0.81 | STAT3 (0.51) | MAPTCCR9SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL18315257 | 0.80 | KEAP1 (0.50) | CCR9SLC40A1LMNAHTTMEN1 | |
| SCHEMBL30304671 | 0.80 | KEAP1 (0.50) | CCR9SLC40A1LMNAHTTMEN1 | |
| SCHEMBL4781379 | 0.79 | TSHR (0.46) | CCR9ALDH1A1LMNAHTTMEN1 | |
| SCHEMBL17843843 | 0.79 | DNMT1 (0.56) | DNMT1DNMT3ASLC25A1SLC10A2SLC10A1 | |
| SCHEMBL3098055 | 0.78 | AXL (0.52) | SLC40A1MEN1KMT2AKEAP1NFE2L2 | |
| SCHEMBL4779121 | 0.76 | KEAP1 (0.45) | MAPTCCR9SMN1; SMN2HPGDSLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234364-A1 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. | 2010-09-16 | — | — | US | disclosed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234364-A1 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CCR2, CCR9, CCR1 | DNMT1 4805/4885DNMT3A 4538/4885SLC25A1 2158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.