Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.44 |
| ▸ | STAT3 | P40763 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CCR9 | P51686 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3095654 | 0.92 | STAT3 (0.51) | TSHRSCN9ASTAT3ALDH1A1CCR9 | |
| SCHEMBL4777554 | 0.91 | PKM (0.46) | TSHRALDH1A1CCR9FFAR4KDM4E | |
| SCHEMBL4781526 | 0.89 | MEN1 (0.48) | TSHRSCN9ASTAT3ALDH1A1CCR9 | |
| SCHEMBL3098055 | 0.85 | AXL (0.52) | SCN9ASTAT3KMT2AKEAP1NFE2L2 | |
| SCHEMBL30304671 | 0.83 | KEAP1 (0.50) | TSHRSTAT3CCR9KMT2ALMNA | |
| SCHEMBL18315257 | 0.83 | KEAP1 (0.50) | TSHRSTAT3CCR9KMT2ALMNA | |
| SCHEMBL4778484 | 0.81 | KMT2A (0.48) | TSHRSCN9ASTAT3ALDH1A1CCR9 | |
| SCHEMBL3097960 | 0.80 | AXL (0.53) | TSHRSCN9AKMT2ALMNANPSR1 | |
| SCHEMBL31478916 | 0.80 | AXL (0.53) | TSHRSCN9AKMT2ALMNANPSR1 | |
| SCHEMBL4780415 | 0.80 | MEN1 (0.57) | ALDH1A1KDM4EKMT2ALMNAKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |