Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 14/20 | 0.41 |
| ▸ | BRAF | P15056 | 8/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | BUB1 | O43683 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PRKACG | P22612 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | ACSL5 | Q9ULC5 | 1/20 | 0.38 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729210 | 0.83 | TRPV1 (0.42) | RAF1BRAFADORA2AMAPK14TRPV1 | |
| SCHEMBL4779963 | 0.81 | BRAF (0.46) | RAF1BRAFKDM4ERAB9A | |
| SCHEMBL4729212 | 0.80 | TRPV1 (0.41) | RAF1BRAFADORA2AMAPK14TRPV1 | |
| SCHEMBL4729484 | 0.80 | TRPV1 (0.41) | RAF1BRAFADORA2AMAPK14TRPV1 | |
| SCHEMBL4726226 | 0.79 | RAF1 (0.46) | RAF1BRAFCYP2C9TRPV1NPC1 | |
| SCHEMBL4728383 | 0.79 | NPC1 (0.52) | RAF1BRAFADORA2ACYP2C9KDM4E | |
| SCHEMBL4726798 | 0.78 | RAF1 (0.42) | RAF1BRAFTRPV1 | |
| SCHEMBL4725914 | 0.78 | RAF1 (0.41) | RAF1BRAFADORA2A | |
| SCHEMBL4781066 | 0.78 | MAPK14 (0.55) | RAF1MAPK14 | |
| SCHEMBL4727602 | 0.78 | RAF1 (0.42) | RAF1BRAFADORA2AMAPK14TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |