Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.46 |
| ▸ | RAF1 | P04049 | 7/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779686 | 0.81 | RAF1 (0.41) | BRAFRAF1KDM4ERAB9A | |
| SCHEMBL4729210 | 0.80 | TRPV1 (0.42) | BRAFRAF1 | |
| SCHEMBL4729212 | 0.79 | TRPV1 (0.41) | BRAFRAF1 | |
| SCHEMBL4729484 | 0.79 | TRPV1 (0.41) | BRAFRAF1 | |
| SCHEMBL14292743 | 0.78 | TRPV1 (0.39) | BRAFRAF1 | |
| SCHEMBL4729549 | 0.78 | BTK (0.40) | BRAFRAF1ALDH1A1MAPTPOLB | |
| SCHEMBL4726226 | 0.78 | RAF1 (0.46) | BRAFRAF1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL4728383 | 0.77 | NPC1 (0.52) | BRAFRAF1LMNAHTTKDM4E | |
| SCHEMBL4729438 | 0.77 | MEN1 (0.54) | BRAFRAF1MAPK1LMNAHTT | |
| SCHEMBL4726798 | 0.77 | RAF1 (0.42) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |