Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779713 | 0.85 | LMNA (0.40) | BRAFCASRRAF1 | |
| SCHEMBL4359620 | 0.80 | HTT (0.51) | — | |
| SCHEMBL4353861 | 0.72 | CLK4 (0.54) | — | |
| SCHEMBL4351977 | 0.67 | PDE3B (0.43) | PDE3BPDE3AP2RY12CYSLTR2CYSLTR1 | |
| SCHEMBL28798228 | 0.67 | PCSK9 (0.56) | CASR | |
| SCHEMBL3951838 | 0.64 | L3MBTL1 (0.66) | — | |
| SCHEMBL27838094 | 0.63 | ALOX5 (0.57) | PDE3BPDE3AP2RY12CYSLTR2CYSLTR1 | |
| SCHEMBL7692039 | 0.63 | LTA4H (0.52) | CYSLTR2CYSLTR1 | |
| SCHEMBL21992555 | 0.63 | MAPT (0.60) | — | |
| SCHEMBL7692040 | 0.63 | LTA4H (0.52) | CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009078-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | claimed |