Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GLS | O94925 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3807279 | 0.83 | TSHR (0.47) | LMNATHRBHDAC1HDAC6FDPS | |
| SCHEMBL16001288 | 0.82 | KMT2A (0.48) | LMNATHRBMEN1KMT2ATSHR | |
| SCHEMBL8187886 | 0.81 | FDPS (0.42) | LMNATHRBHDAC1HDAC6FDPS | |
| SCHEMBL1259755 | 0.79 | TDP1 (0.41) | LMNATHRBHDAC1HDAC6FDPS | |
| Hydrochloric Acid SCHEMBL8187346 | 0.79 | FDPS (0.41) | LMNATHRBHDAC1HDAC6FDPS | |
| SCHEMBL1259224 | 0.77 | ALDH1A1 (0.51) | LMNAHDAC6MEN1KMT2AGLS | |
| SCHEMBL27937039 | 0.77 | KEAP1 (0.42) | LMNATHRBHDAC1HDAC6MEN1 | |
| SCHEMBL7030414 | 0.77 | NLRP3 (0.46) | LMNATHRBHDAC1HDAC6MEN1 | |
| SCHEMBL8719580 | 0.76 | MEN1 (0.43) | LMNAMEN1KMT2ATSHRCYP1A2 | |
| SCHEMBL19022012 | 0.74 | GLS (0.47) | LMNATHRBHDAC1HDAC6FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893610-A2 | ALPHA-(ARYL-OR HETEROARYL-METHYL)-BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONISTS | Pfizer, Inc. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006134486-A2 | ALPHA-(ARYL-OR HETEROARYL-METHYL)-BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONISTS | PFIZER JAPAN INC. (JP) | 2006-12-21 | — | — | WO | disclosed |