Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1522685 | 0.87 | MMP8 (0.64) | MMP8ALDH1A1TP53NPY1RNPY2R | |
| SCHEMBL4780409 | 0.86 | MMP8 (0.48) | MMP8ALOX5SMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL4778301 | 0.84 | LMNA (0.50) | MMP8ALOX5SMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL4779783 | 0.84 | TDP1 (0.49) | MMP8ALOX5SMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL165382 | 0.83 | MMP8 (0.76) | MMP8ALDH1A1TP53NPY1RNPY2R | |
| SCHEMBL3467791 | 0.83 | LDHA (0.55) | MMP8ALOX5ALDH1A1TP53MAPT | |
| SCHEMBL4780672 | 0.82 | ALOX5 (0.52) | ALOX5SMN1; SMN2HDAC3HDAC4HDAC1 | |
| SCHEMBL17203012 | 0.82 | MMP8 (0.66) | MMP8ALDH1A1TP53NPY1RNPY2R | |
| SCHEMBL7060674 | 0.82 | TDP1 (0.49) | MMP8ALOX5SMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL467987 | 0.81 | MMP8 (0.73) | MMP8ALDH1A1TP53NPY1RNPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |