Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 14/20 | 0.40 |
| ▸ | BRAF | P15056 | 14/20 | 0.40 |
| ▸ | TEK | Q02763 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | BCR | P11274 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.37 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780120 | 0.90 | DDR1 (0.35) | BRAFABL1BCRHIF1AEPAS1 | |
| SCHEMBL4781343 | 0.83 | BRAF (0.53) | RAF1BRAF | |
| SCHEMBL4779088 | 0.82 | DDR2 (0.38) | BRAFABL1BCRDDR1DDR2 | |
| SCHEMBL4778561 | 0.82 | DDT (0.45) | — | |
| SCHEMBL4782663 | 0.81 | MAPK14 (0.38) | — | |
| SCHEMBL4779210 | 0.81 | TEK (0.41) | RAF1BRAFTEK | |
| SCHEMBL4728307 | 0.81 | RAF1 (0.45) | RAF1BRAF | |
| SCHEMBL4728240 | 0.81 | RAF1 (0.49) | RAF1BRAF | |
| SCHEMBL4784000 | 0.80 | DDT (0.34) | RAF1BRAF | |
| SCHEMBL4782092 | 0.79 | BRAF (0.34) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |