Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.34 |
| ▸ | HTR1D | P28221 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | DDT | P30046 | 2/20 | 0.33 |
| ▸ | RAF1 | P04049 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782091 | 0.92 | BRAF (0.32) | BRAFHTR1DSLC6A4DDTMAPT | |
| SCHEMBL4778561 | 0.83 | DDT (0.45) | DDTTP53RAB9A | |
| SCHEMBL4779210 | 0.82 | TEK (0.41) | BRAFDDTRAF1 | |
| SCHEMBL4784000 | 0.82 | DDT (0.34) | BRAFDDTRAF1MEN1MAPT | |
| SCHEMBL4782663 | 0.81 | MAPK14 (0.38) | DDTHTR1A | |
| SCHEMBL14293723 | 0.80 | MAPK14 (0.42) | BRAFHTR1DSLC6A4RAF1MEN1 | |
| SCHEMBL4780132 | 0.79 | RAF1 (0.40) | BRAFRAF1 | |
| SCHEMBL4730805 | 0.79 | DDT (0.42) | BRAFDDTRAF1 | |
| SCHEMBL4783784 | 0.76 | TEK (0.40) | BRAFDDTRAF1 | |
| SCHEMBL4782901 | 0.75 | BRAF (0.45) | BRAFDDTRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |