Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | DDX3X | O00571 | 1/20 | 0.46 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18315257 | 0.85 | KEAP1 (0.50) | MEN1KMT2ATDP1LMNAPOLB | |
| SCHEMBL30304671 | 0.85 | KEAP1 (0.50) | MEN1KMT2ATDP1LMNAPOLB | |
| SCHEMBL3098055 | 0.84 | AXL (0.52) | MEN1KMT2APGRKEAP1NFE2L2 | |
| SCHEMBL3083474 | 0.84 | DNMT1 (0.46) | MEN1KMT2ATDP1L3MBTL1ALDH1A1 | |
| SCHEMBL4779121 | 0.83 | KEAP1 (0.45) | MEN1KMT2ATDP1ALDH1A1MAPT | |
| SCHEMBL4777554 | 0.82 | PKM (0.46) | MEN1KMT2ATDP1L3MBTL1ALDH1A1 | |
| SCHEMBL31478916 | 0.82 | AXL (0.53) | MEN1KMT2APLAUARLMNA | |
| SCHEMBL3097960 | 0.82 | AXL (0.53) | MEN1KMT2APLAUARLMNA | |
| SCHEMBL3095654 | 0.81 | STAT3 (0.51) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL4781379 | 0.80 | TSHR (0.46) | MEN1KMT2AALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |