Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CCR9 | P51686 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781379 | 0.91 | TSHR (0.46) | FFAR4ALDH1A1LMNAHTTKDM4E | |
| SCHEMBL3095654 | 0.86 | STAT3 (0.51) | ALDH1A1LMNAHTTKDM4ECCR9 | |
| SCHEMBL30304671 | 0.86 | KEAP1 (0.50) | LMNAHTTCCR9KMT2AMEN1 | |
| SCHEMBL18315257 | 0.86 | KEAP1 (0.50) | LMNAHTTCCR9KMT2AMEN1 | |
| SCHEMBL4775781 | 0.85 | ALDH1A1 (0.46) | PKMALDH1A1LMNAHTTMCOLN3 | |
| SCHEMBL4781526 | 0.84 | MEN1 (0.48) | PKMALDH1A1LMNAHTTCCR9 | |
| SCHEMBL3098055 | 0.83 | AXL (0.52) | KMT2AMEN1GAAKEAP1NFE2L2 | |
| SCHEMBL4780415 | 0.82 | MEN1 (0.57) | ALDH1A1LMNAL3MBTL1KDM4EKMT2A | |
| SCHEMBL4779121 | 0.82 | KEAP1 (0.45) | PKMFFAR4ALDH1A1LMNAHTT | |
| SCHEMBL3083474 | 0.81 | DNMT1 (0.46) | ALDH1A1LMNAHTTL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |