Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782157 | 0.72 | NOTUM (0.37) | ALDH1A1MAPT | |
| SCHEMBL4782153 | 0.72 | NOTUM (0.37) | ALDH1A1MAPT | |
| SCHEMBL4780603 | 0.69 | DRD2 (0.38) | NPC1ALDH1A1CYP2C19MAPTRAB9A | |
| SCHEMBL200191 | 0.69 | CYP2C19 (0.46) | NPC1CYP19A1KMT2ACYP2C19ATM | |
| SCHEMBL14293533 | 0.67 | KMT2A (0.34) | KMT2AALDH1A1MEN1MAPTRXFP1 | |
| SCHEMBL21666580 | 0.65 | ALDH1A1 (0.43) | NPC1KMT2AALDH1A1CYP2C19MAPT | |
| SCHEMBL21666421 | 0.65 | ALDH1A1 (0.43) | NPC1KMT2AALDH1A1CYP2C19MEN1 | |
| SCHEMBL4781744 | 0.65 | MAPT (0.32) | KMT2AALDH1A1ATMMAPT | |
| SCHEMBL16423665 | 0.65 | CYP2C19 (0.62) | NPC1KMT2AALDH1A1CYP2C19MAPT | |
| SCHEMBL22752410 | 0.63 | ALDH1A1 (0.46) | NPC1KMT2AALDH1A1MEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |