Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782153 | 1.00 | NOTUM (0.37) | NOTUMKEAP1NFE2L2MAPK1MAPT | |
| SCHEMBL14292732 | 0.84 | GPR119 (0.38) | NOTUMMAPTPOLB | |
| SCHEMBL14293533 | 0.84 | KMT2A (0.34) | MAPTALDH1A1TGM2SMN1; SMN2POLB | |
| SCHEMBL4780603 | 0.81 | DRD2 (0.38) | NOTUMMAPTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4781744 | 0.75 | MAPT (0.32) | MAPK1MAPTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4782960 | 0.73 | CYP2C19 (0.46) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL13436194 | 0.73 | CHEK1 (0.40) | KEAP1NFE2L2 | |
| SCHEMBL4781747 | 0.72 | NPC1 (0.37) | MAPTALDH1A1 | |
| SCHEMBL14293528 | 0.71 | PKM (0.37) | MAPTALDH1A1TDP1SMN1; SMN2POLB | |
| SCHEMBL31162142 | 0.70 | NOTUM (0.41) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |