Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 4/20 | 0.52 |
| ▸ | CCR8 | P51685 | 14/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | WNT3 | P56703 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784223 | 0.89 | HTR1A (0.42) | SFRP1CCR8HTR1AHTR7WNT3 | |
| SCHEMBL4783673 | 0.86 | CCR8 (0.51) | CCR8 | |
| SCHEMBL4785194 | 0.85 | SFRP1 (0.65) | SFRP1WNT3 | |
| SCHEMBL14208234 | 0.84 | HTR6 (0.49) | SFRP1CCR8WNT3 | |
| SCHEMBL4802468 | 0.84 | HTR1A (0.46) | HTR1AHTR7 | |
| SCHEMBL14207899 | 0.82 | HTR6 (0.43) | HTR1AHTR7 | |
| SCHEMBL4781850 | 0.82 | SFRP1 (0.44) | SFRP1CCR8HTR1AHTR7 | |
| SCHEMBL4782531 | 0.82 | SFRP1 (0.53) | SFRP1HTR1AHTR7 | |
| SCHEMBL4784467 | 0.82 | HTR6 (0.42) | HTR1AHTR7 | |
| SCHEMBL4783875 | 0.81 | HTR6 (0.56) | SFRP1HTR1AHTR7WNT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |