Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 13/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14208234 | 0.90 | HTR6 (0.49) | CCR8ALDH1A1 | |
| SCHEMBL4784223 | 0.90 | HTR1A (0.42) | CCR8 | |
| SCHEMBL4785454 | 0.88 | CCR8 (0.51) | CCR8ALDH1A1SMN1; SMN2LMNAUSP2 | |
| SCHEMBL4782745 | 0.86 | SFRP1 (0.52) | CCR8 | |
| SCHEMBL4802468 | 0.85 | HTR1A (0.46) | — | |
| SCHEMBL4781850 | 0.85 | SFRP1 (0.44) | CCR8 | |
| SCHEMBL14207899 | 0.83 | HTR6 (0.43) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4782531 | 0.82 | SFRP1 (0.53) | ALDH1A1 | |
| SCHEMBL4784467 | 0.82 | HTR6 (0.42) | SMN1; SMN2LMNA | |
| SCHEMBL4782045 | 0.81 | HTR6 (0.45) | CCR8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |