Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 10/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4800128 | 0.88 | HTR6 (0.43) | ALDH1A1MAPTHTR6BRD4HTR1A | |
| SCHEMBL14208209 | 0.88 | HTR6 (0.54) | ALDH1A1HTR6L3MBTL1SFRP1HTR1A | |
| SCHEMBL4781316 | 0.88 | HTR6 (0.43) | ALDH1A1MAPTHTR6BRD4SFRP1 | |
| SCHEMBL4782603 | 0.86 | BRD4 (0.43) | ALDH1A1MAPTHTR6BRD4CCR8 | |
| SCHEMBL4781473 | 0.85 | SFRP1 (0.46) | HTR6SFRP1HTR1AHTR7 | |
| SCHEMBL4785881 | 0.85 | HTR6 (0.41) | ALDH1A1MAPTHTR6L3MBTL1BRD4 | |
| SCHEMBL4782045 | 0.85 | HTR6 (0.45) | ALDH1A1MAPTHTR6BRD4HTR1A | |
| SCHEMBL4782093 | 0.85 | NPC1 (0.48) | ALDH1A1HTR6 | |
| SCHEMBL4785454 | 0.80 | CCR8 (0.51) | ALDH1A1L3MBTL1CCR8 | |
| SCHEMBL4782095 | 0.76 | HTR6 (0.48) | ALDH1A1HTR6HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |