Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | HTR7 | P34969 | 3/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782935 | 0.88 | ALDH1A1 (0.43) | HTR6MAPTBRD4ALDH1A1HTR1A | |
| SCHEMBL4781316 | 0.88 | HTR6 (0.43) | HTR6MAPTBRD4ALDH1A1HTR1A | |
| SCHEMBL4784843 | 0.88 | HTR6 (0.54) | HTR6MAPTHTR1AHTR7CCR8 | |
| SCHEMBL4782603 | 0.86 | BRD4 (0.43) | HTR6MAPTBRD4ALDH1A1CCR8 | |
| SCHEMBL4785881 | 0.85 | HTR6 (0.41) | HTR6MAPTBRD4ALDH1A1 | |
| SCHEMBL4781473 | 0.85 | SFRP1 (0.46) | HTR6HTR1AHTR7 | |
| SCHEMBL4782045 | 0.85 | HTR6 (0.45) | HTR6MAPTBRD4ALDH1A1HTR1A | |
| SCHEMBL4780971 | 0.83 | BRD4 (0.45) | HTR6BRD4 | |
| SCHEMBL14207864 | 0.80 | SFRP1 (0.47) | HTR6CCR8 | |
| SCHEMBL4783125 | 0.80 | CCR8 (0.52) | HTR6BRD4CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |