Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | IL1B | P01584 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | AQP1 | P29972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783496 | 0.88 | NPC1 (0.46) | NPC1ALDH1A1PKMGBA1HTR6 | |
| SCHEMBL4782615 | 0.87 | NPC1 (0.46) | NPC1ALDH1A1PKMGBA1HTR6 | |
| SCHEMBL4783430 | 0.86 | CNR2 (0.48) | NPC1ALDH1A1PKMGBA1HTR6 | |
| SCHEMBL4782077 | 0.86 | NPC1 (0.44) | NPC1ALDH1A1PKMGBA1HTR6 | |
| SCHEMBL4782935 | 0.85 | ALDH1A1 (0.43) | ALDH1A1HTR6 | |
| SCHEMBL4780971 | 0.79 | BRD4 (0.45) | NPC1HTR6 | |
| SCHEMBL4783073 | 0.77 | HTR6 (0.45) | HTR6SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4783889 | 0.77 | BRD4 (0.43) | NPC1HTR6 | |
| SCHEMBL4782487 | 0.75 | HTR6 (0.48) | HTR6 | |
| SCHEMBL14208209 | 0.75 | HTR6 (0.54) | ALDH1A1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |