SCHEMBL4784060

SCHEMBL4784060

CCCCCS(=O)(=O)C(F)(F)F

nearest known ligand 0.52

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FAAH O00519 7/20 0.52
CA2 P00918 5/20 0.50
CES1 P23141 5/20 0.47
CES2 O00748 2/20 0.47
EPHX1 P07099 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6001999 1.00 FAAH (0.52) FAAHCA2CES1CES2EPHX1
SCHEMBL4076093 0.98 FAAH (0.56) FAAHCA2CES1CES2EPHX1
SCHEMBL23520532 0.98 FAAH (0.56) FAAHCA2CES1CES2EPHX1
SCHEMBL13864077 0.98 FAAH (0.56) FAAHCA2CES1CES2EPHX1
SCHEMBL10002197 0.92 EPHX1 (0.43) FAAHCA2CES1CES2EPHX1
SCHEMBL5469606 0.87 CA2 (0.37) FAAHCA2CES1CES2EPHX1
SCHEMBL5457097 0.84 CA2 (0.37) FAAHCA2CES1CES2EPHX1
SCHEMBL17092516 0.84 CA2 (0.37) FAAHCA2CES1CES2EPHX1
SCHEMBL6895720 0.81 EPHX1 (0.37) FAAHCA2CES1CES2EPHX1
SCHEMBL21414876 0.81 CA1 (0.37) CA2EPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113527158-B Method for constructing fluorine-containing methyl sulfone compound by multi-component coupling 华东师范大学 2023-02-07 CN disclosed
CN-113527158-A Method for constructing fluorine-containing methyl sulfone compound by multi-component coupling 华东师范大学 2021-10-22 CN disclosed
US-11022884-B2 Silicon-containing resist underlayer film-forming composition having halogenated sulfonylalkyl group NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2021-06-01 US disclosed
US-20170296585-A1 IDENTIFICATION AND ISOLATION OF MULTIPOTENT CELLS FROM NON-OSTEOCHONDRAL MESENCHYMAL TISSUE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-10-19 US disclosed
US-9751049-B2 Compositions and methods of cleaning polyvinyl pyrrolidone-based hemodialysis filtration membrane assemblies NOVAFLUX INC. (US) 2017-09-05 US disclosed
US-20170168397-A1 SILICON-CONTAINING RESIST UNDERLAYER FILM-FORMING COMPOSITION HAVING HALOGENATED SULFONYLALKYL GROUP NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2017-06-15 US disclosed
US-9063416-B2 Resist composition, method of forming resist pattern and compound TOKYO OHKA KOGYO CO., LTD. (JP) 2015-06-23 US disclosed
US-20130157197-A1 RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN AND COMPOUND TOKYO OHKA KOGYO CO., LTD. (JP) 2013-06-20 US disclosed
EP-2128980-A2 Acoustic wave device and high-frequency filter using the same Hitachi Ltd. (JP) 2009-12-02 EP disclosed
WO-2008060999-A1 PIPERIDINYL ARYLSULFONE DERIVATIVES AS MODULATORS OF SECRETED FRIZZLED RELATED PROTEIN-1 WYETH (US) 2008-05-22 WO disclosed
EP-1212296-B9 PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS SUGEN INC (US) 2006-05-10 EP disclosed
EP-1212296-B1 PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS SUGEN INC (US) 2005-11-09 EP disclosed
US-20040230079-A1 Methods for nucleophilic fluoromethylation SOUTHERN CALIFORNIA, UNIVERSITY OF 2004-11-18 US disclosed
WO-2004063129-A2 METHODS FOR NUCLEOPHILIC FLUOROMETHYLATION UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2004-07-29 WO disclosed
US-20040138255-A1 Phosphate mimics and methods of treatment using phosphatease inhibitors SUGEN, INC. 2004-07-15 US disclosed
US-6596772-B1 Relates to trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds and the physiologically acceptable salts and the prodrugs thereof. These compounds are expected to modulate the activity of protein tyrosine enzymes which are SUGEN, INC. 2003-07-22 US disclosed
EP-1212296-A1 PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS Sugen, Inc. (US) 2002-06-12 EP disclosed
US-6403802-B1 MIXING IN LIQUID MEDIUM STRONG BASE, ARYL HALIDE OR ARYL PSEUDOHALIDE, PRIMARY AND/OR SECONDARY AMINE, NICKEL, PALLADIUM OR PLATINUM COMPOUND, N-HETEROCYCLIC CARBENE SUCH AS IMIDAZOLINE-2-YLIDENE, BIS(IMIDAZOLINE-2-YLIDENE) OR SALTS UNIVERSITY OF NEW ORLEANS RESEARCH & TECHNOLOGY FOUNDATION 2002-06-11 US disclosed
WO-2001066248-A2 C-C AND C-N COUPLING CATALYST COMPRISING TRANSITION METAL AND CARBENE UNIVERSITY OF NEW ORLEANS RESEARCH AND TECHNOLOGY FOUNDATION (US) 2001-09-13 WO disclosed
WO-2001016097-A1 PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS SUGEN, INC. (US) 2001-03-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040230079-A1 Methods for nucleophilic fluoromethylation PHF2, HAO2, GSTM2 FAAH 1042/4885CA2 204/4885CES1 662/4885
US-20040138255-A1 Phosphate mimics and methods of treatment using phosphatease inhibitors PPP4C, PTPRO, PTPRS FAAH 4379/4885CA2 283/4885CES1 1242/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.