Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.52 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.42 |
| ▸ | WNT3 | P56703 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4785881 | 0.88 | HTR6 (0.41) | HTR6SFRP1DRD2HTR2CHTR2A | |
| SCHEMBL4782800 | 0.86 | CTSB (0.39) | HTR6SFRP1WNT3 | |
| SCHEMBL4784843 | 0.85 | HTR6 (0.54) | HTR6SFRP1WNT3DRD2DRD3 | |
| SCHEMBL14208209 | 0.85 | HTR6 (0.54) | HTR6SFRP1WNT3DRD2DRD3 | |
| SCHEMBL4782711 | 0.83 | HTR6 (0.52) | HTR6SFRP1WNT3DRD2DRD3 | |
| SCHEMBL4783875 | 0.82 | HTR6 (0.56) | HTR6SFRP1WNT3DRD2DRD3 | |
| SCHEMBL4782529 | 0.82 | SFRP1 (0.56) | HTR6SFRP1WNT3DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL4781661 | 0.82 | SFRP1 (0.55) | HTR6SFRP1WNT3DRD2DRD3 | |
| SCHEMBL4782687 | 0.79 | SFRP1 (0.49) | SFRP1CCR8 | |
| SCHEMBL4783234 | 0.78 | CCR8 (0.43) | CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |