Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSC | P53634 | 2/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | SFRP1 | Q8N474 | 10/20 | 0.39 |
| ▸ | HTR6 | P50406 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | WNT3 | P56703 | 2/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782687 | 0.87 | SFRP1 (0.49) | SFRP1 | |
| SCHEMBL4784244 | 0.86 | HTR6 (0.52) | SFRP1HTR6WNT3 | |
| SCHEMBL4785881 | 0.86 | HTR6 (0.41) | CTSBCTSKUCHL1CTSSCTSC | |
| SCHEMBL4783234 | 0.85 | CCR8 (0.43) | HRH2HRH1 | |
| SCHEMBL4782499 | 0.84 | HTR6 (0.42) | SFRP1HTR6WNT3 | |
| SCHEMBL4783460 | 0.83 | SFRP1 (0.50) | SFRP1WNT3 | |
| SCHEMBL4784223 | 0.83 | HTR1A (0.42) | SFRP1HTR6WNT3 | |
| SCHEMBL4734261 | 0.80 | HRH2 (0.51) | CTSBCTSKUCHL1CTSSCTSC | |
| SCHEMBL4781544 | 0.80 | SFRP1 (0.44) | SFRP1HTR6THRB | |
| SCHEMBL4879740 | 0.78 | SFRP1 (0.47) | SFRP1WNT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |