Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 11/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | CCR8 | P51685 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782800 | 0.87 | CTSB (0.39) | SFRP1 | |
| SCHEMBL4781544 | 0.83 | SFRP1 (0.44) | SFRP1CCR8 | |
| SCHEMBL4783234 | 0.80 | CCR8 (0.43) | CCR8 | |
| SCHEMBL4781750 | 0.79 | SFRP1 (0.57) | SFRP1 | |
| SCHEMBL14207864 | 0.79 | SFRP1 (0.47) | SFRP1CCR8 | |
| SCHEMBL4784244 | 0.79 | HTR6 (0.52) | SFRP1CCR8 | |
| SCHEMBL4785881 | 0.79 | HTR6 (0.41) | SFRP1 | |
| SCHEMBL4784924 | 0.78 | SFRP1 (0.55) | SFRP1 | |
| SCHEMBL4781850 | 0.77 | SFRP1 (0.44) | SFRP1MEN1KMT2ACCR8 | |
| SCHEMBL4782499 | 0.74 | HTR6 (0.42) | SFRP1CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |