Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783444 | 0.90 | TBXAS1 (0.48) | HTR6 | |
| SCHEMBL4785772 | 0.86 | HTR6 (0.45) | HTR6MAPT | |
| SCHEMBL4784929 | 0.84 | ALDH1A1 (0.45) | NSD2ALDH1A1PRMT1HSD17B10HTR6 | |
| SCHEMBL4784291 | 0.80 | TDP1 (0.54) | ALDH1A1HTR6SFRP1 | |
| SCHEMBL4784579 | 0.80 | TDP1 (0.54) | ALDH1A1HTR6MAPT | |
| SCHEMBL4780971 | 0.80 | BRD4 (0.45) | HTR6HDAC2HDAC8HDAC6 | |
| SCHEMBL14207886 | 0.79 | ALDH1A1 (0.46) | ALDH1A1HTR6 | |
| SCHEMBL4780287 | 0.78 | ALDH1A1 (0.48) | ALDH1A1HTR6SFRP1 | |
| SCHEMBL4783865 | 0.78 | TBXAS1 (0.48) | ALDH1A1 | |
| SCHEMBL4780521 | 0.78 | TBXAS1 (0.48) | ALDH1A1SFRP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |