Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 16/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783889 | 0.86 | BRD4 (0.43) | BRD4HTR6NPC1BCHE | |
| SCHEMBL4800128 | 0.83 | HTR6 (0.43) | BRD4HTR6 | |
| SCHEMBL4784750 | 0.80 | NSD2 (0.46) | HTR6HDAC2HDAC8HDAC6 | |
| SCHEMBL4782093 | 0.79 | NPC1 (0.48) | HTR6NPC1 | |
| SCHEMBL4783496 | 0.79 | NPC1 (0.46) | HTR6NPC1 | |
| SCHEMBL4783430 | 0.79 | CNR2 (0.48) | HTR6NPC1 | |
| SCHEMBL4782615 | 0.78 | NPC1 (0.46) | HTR6NPC1 | |
| SCHEMBL4782077 | 0.77 | NPC1 (0.44) | HTR6NPC1BCHE | |
| SCHEMBL4785772 | 0.75 | HTR6 (0.45) | HTR6 | |
| SCHEMBL14207886 | 0.75 | ALDH1A1 (0.46) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |