Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | XPO1 | O14980 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787911 | 0.87 | TRPM8 (0.47) | TRPM8L3MBTL1MAPTALDH1A1MEN1 | |
| SCHEMBL4787840 | 0.83 | MAPK1 (0.40) | GABRA2GABRB2MAPTKMT2ANPSR1 | |
| SCHEMBL28746466 | 0.82 | TRPM8 (0.53) | TRPM8GABRA2GABRB2L3MBTL1MAPT | |
| SCHEMBL29565728 | 0.82 | TRPM8 (0.53) | TRPM8GABRA2GABRB2L3MBTL1MAPT | |
| SCHEMBL4909055 | 0.80 | MEN1 (0.40) | MAPTALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL4788567 | 0.79 | GAA (0.51) | GABRA2GABRB2L3MBTL1MAPTALDH1A1 | |
| SCHEMBL4787716 | 0.77 | SMN1; SMN2 (0.48) | MAPTALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL4788014 | 0.74 | MAPT (0.41) | MAPTALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL28800116 | 0.71 | GABRA2 (0.52) | TRPM8GABRA2GABRB2MAPTALDH1A1 | |
| SCHEMBL29800446 | 0.71 | GABRA2 (0.52) | TRPM8GABRA2GABRB2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008111794-A1 | 4-METHYLIMIDAZOL-5-YLCARBONYLGUANIDINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF THE ISCHEMIC HEART DISEASES CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-09-18 | — | — | WO | disclosed |