Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.40 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4909055 | 0.89 | MEN1 (0.40) | MAPK1MAPTKDM4ESMN1; SMN2SLC5A1 | |
| SCHEMBL4785279 | 0.83 | TRPM8 (0.47) | MAPK1MAPTKDM4ESMN1; SMN2NPSR1 | |
| SCHEMBL4787716 | 0.80 | SMN1; SMN2 (0.48) | MAPK1MAPTKDM4ESMN1; SMN2GAA | |
| SCHEMBL4788014 | 0.74 | MAPT (0.41) | MAPK1MAPTKDM4ESMN1; SMN2GAA | |
| SCHEMBL4788567 | 0.74 | GAA (0.51) | MAPK1MAPTKDM4ESMN1; SMN2GAA | |
| SCHEMBL14740062 | 0.67 | CYP1A2 (0.65) | MAPK1KDM4ESMN1; SMN2NPSR1RAB9A | |
| SCHEMBL14739667 | 0.67 | CYP1A2 (0.52) | MAPK1MAPTKDM4ESMN1; SMN2GABRA2 | |
| SCHEMBL25234831 | 0.67 | CYP2C9 (0.54) | MAPTKDM4ESMN1; SMN2GAANPSR1 | |
| SCHEMBL28746461 | 0.67 | MAPK1 (0.53) | MAPK1MAPTKDM4ESMN1; SMN2NPSR1 | |
| SCHEMBL11225504 | 0.67 | CYP4F2 (0.67) | MAPK1MAPTKDM4ETSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008111794-A1 | 4-METHYLIMIDAZOL-5-YLCARBONYLGUANIDINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF THE ISCHEMIC HEART DISEASES CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-09-18 | — | — | WO | disclosed |