Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787716 | 0.82 | SMN1; SMN2 (0.48) | MAPTSMN1; SMN2LMNAMAPK1HSD17B10 | |
| SCHEMBL4909055 | 0.80 | MEN1 (0.40) | MAPTSMN1; SMN2MAPK1KDM4EALDH1A1 | |
| SCHEMBL4788567 | 0.77 | GAA (0.51) | MAPTSMN1; SMN2LMNAPKMMAPK1 | |
| SCHEMBL4787840 | 0.74 | MAPK1 (0.40) | MAPTSMN1; SMN2MAPK1HSD17B10KDM4E | |
| SCHEMBL4785279 | 0.74 | TRPM8 (0.47) | MAPTSMN1; SMN2LMNAMAPK1KDM4E | |
| SCHEMBL29881000 | 0.66 | MEN1 (0.47) | MAPTSMN1; SMN2LMNAPKMMAPK1 | |
| SCHEMBL22440198 | 0.66 | MEN1 (0.47) | MAPTSMN1; SMN2LMNAPKMMAPK1 | |
| SCHEMBL27707738 | 0.66 | NFE2L2 (0.49) | MAPTSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL7688461 | 0.66 | KMT2A (0.65) | MAPTSMN1; SMN2LMNAHSD17B10KDM4E | |
| SCHEMBL4788025 | 0.65 | PKM (0.44) | MAPTSMN1; SMN2LMNAPKMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008111794-A1 | 4-METHYLIMIDAZOL-5-YLCARBONYLGUANIDINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF THE ISCHEMIC HEART DISEASES CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-09-18 | — | — | WO | disclosed |