Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.38 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787840 | 0.89 | MAPK1 (0.40) | KMT2AMAPK1SMN1; SMN2POLBTSHR | |
| SCHEMBL4788014 | 0.80 | MAPT (0.41) | MEN1KMT2AMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4785279 | 0.80 | TRPM8 (0.47) | MEN1KMT2AMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4787716 | 0.77 | SMN1; SMN2 (0.48) | MEN1KMT2AMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4788567 | 0.76 | GAA (0.51) | MEN1KMT2AMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5377655 | 0.71 | GABRA2 (0.47) | MEN1KMT2AMAPK1HTTCTSA | |
| SCHEMBL29654067 | 0.70 | JAK2 (0.51) | MEN1KMT2AALDH1A1POLBTSHR | |
| SCHEMBL931470 | 0.70 | JAK2 (0.51) | MEN1KMT2AALDH1A1POLBTSHR | |
| SCHEMBL15920391 | 0.69 | TP53 (0.44) | MEN1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL4729820 | 0.69 | LMNA (0.61) | MEN1KMT2AMAPK1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008111794-A1 | 4-METHYLIMIDAZOL-5-YLCARBONYLGUANIDINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF THE ISCHEMIC HEART DISEASES CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-09-18 | — | — | WO | disclosed |