Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788529 | 0.88 | HTR2A (0.38) | ALDH1A1CYP11B2CYP11B1ADORA2AADORA1 | |
| SCHEMBL4786612 | 0.83 | ALDH1A1 (0.39) | ALDH1A1ADORA2AADORA1NAMPTHPGD | |
| SCHEMBL4751106 | 0.83 | GABRG2 (0.41) | ALDH1A1CYP11B2CYP11B1ADORA2AADORA1 | |
| SCHEMBL4747756 | 0.80 | HRH3 (0.39) | ALDH1A1ADORA2AADORA1NOTUMKDM4E | |
| SCHEMBL4747297 | 0.80 | HRH3 (0.42) | ALDH1A1ADORA2AADORA1NAMPTKDM4E | |
| SCHEMBL4786809 | 0.78 | GAA (0.45) | ALDH1A1KDM4EMAPTHPGDNPSR1 | |
| SCHEMBL4788585 | 0.77 | CASP3 (0.43) | ADORA2AADORA1MAPTRAB9AMEN1 | |
| SCHEMBL4750242 | 0.76 | HRH3 (0.58) | — | |
| SCHEMBL4750215 | 0.76 | PDGFRB (0.42) | ALDH1A1ADORA2AADORA1KDM4EMAPT | |
| SCHEMBL4788225 | 0.75 | HRH3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123755-A1 | A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA | SK CHEMICALS CO., LTD. (KR) | 2008-10-16 | — | — | WO | claimed |
| WO-2008123755-A1 | A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA | SK CHEMICALS CO., LTD. (KR) | 2008-10-16 | — | — | WO | disclosed |