Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 7/20 | 0.44 |
| ▸ | PKLR | P30613 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739848 | 0.91 | NPC1 (0.46) | CYP3A4CYP2C19PKMPKLRLMNA | |
| SCHEMBL4736673 | 0.89 | ALDH1A1 (0.50) | CYP3A4CYP2C19PKMLMNASMN1; SMN2 | |
| SCHEMBL4738918 | 0.84 | CYP3A4 (0.67) | CYP3A4CYP2C19LMNAPOLBSMN1; SMN2 | |
| SCHEMBL4740143 | 0.84 | CYP3A4 (0.67) | CYP3A4CYP2C19LMNAPOLBSMN1; SMN2 | |
| SCHEMBL4737593 | 0.84 | LMNA (0.57) | CYP3A4CYP2C19LMNAPOLBSMN1; SMN2 | |
| SCHEMBL4736709 | 0.84 | LMNA (0.57) | CYP3A4CYP2C19LMNAPOLBSMN1; SMN2 | |
| SCHEMBL4739753 | 0.83 | CYP3A4 (0.68) | CYP3A4CYP2C19PKMLMNAPOLB | |
| SCHEMBL4740746 | 0.83 | CYP3A4 (0.50) | CYP3A4CYP2C19LMNAPOLBSMN1; SMN2 | |
| SCHEMBL4736649 | 0.83 | CYP3A4 (0.50) | CYP3A4CYP2C19LMNAPOLBSMN1; SMN2 | |
| SCHEMBL4740901 | 0.81 | CYP19A1 (0.58) | CYP3A4CYP2C19LMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | claimed |
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | disclosed |