Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PKLR | P30613 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788589 | 0.90 | PKLR (0.45) | ALDH1A1MAPK1POLBMAPTGAA | |
| SCHEMBL4786573 | 0.89 | CCR1 (0.43) | ALDH1A1ALOX15LMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL4786465 | 0.89 | PKLR (0.47) | ALDH1A1LMNASMN1; SMN2MAPK1HTT | |
| SCHEMBL4788750 | 0.87 | HSD11B1 (0.47) | ALDH1A1ALOX15LMNAHSD17B10MAPK1 | |
| SCHEMBL4785661 | 0.85 | KMT2A (0.50) | ALDH1A1LMNAHSD17B10SMN1; SMN2MAPK1 | |
| SCHEMBL4787598 | 0.85 | PKLR (0.48) | ALDH1A1MEN1KMT2AGAAPKLR | |
| SCHEMBL4786322 | 0.85 | PKLR (0.45) | ALDH1A1ALOX15SMN1; SMN2MAPK1HTT | |
| SCHEMBL4784226 | 0.84 | KMT2A (0.46) | ALDH1A1ALOX15LMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL4786988 | 0.83 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10SMN1; SMN2MAPK1 | |
| SCHEMBL4788077 | 0.83 | PKLR (0.47) | ALDH1A1GAAPKLRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | claimed |
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | disclosed |