Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 9/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789135 | 0.82 | KCNH2 (0.47) | KCNH2SCN9ASCN5ALMNAHDAC1 | |
| SCHEMBL4788153 | 0.76 | NOD1 (0.56) | KCNH2SCN9ASCN5ADRD2LMNA | |
| SCHEMBL4788501 | 0.74 | KCNH2 (0.72) | KCNH2SCN9ASCN5ADRD2LMNA | |
| SCHEMBL4785773 | 0.74 | KCNH2 (0.72) | KCNH2SCN9ASCN5ADRD2LMNA | |
| SCHEMBL4789252 | 0.74 | KCNH2 (0.50) | KCNH2SCN9ASCN5ADRD2SMN1; SMN2 | |
| SCHEMBL841303 | 0.72 | SCN9A (0.71) | KCNH2SCN9ASCN5ALMNAHDAC1 | |
| SCHEMBL4788313 | 0.72 | KCNH2 (0.55) | KCNH2SCN9ASCN5ALMNASMN1; SMN2 | |
| SCHEMBL4786769 | 0.71 | KDM4E (0.46) | LMNAHTTSMN1; SMN2NPSR1TSHR | |
| SCHEMBL4786772 | 0.71 | MTNR1A (0.49) | KCNH2SCN9ASCN5ADRD2 | |
| SCHEMBL4787985 | 0.70 | MTNR1A (0.48) | KCNH2SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |