Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | AVPR1B | P47901 | 3/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787412 | 0.92 | TP53 (0.49) | ALDH1A1HPGDGAAHTTTP53 | |
| SCHEMBL4786223 | 0.83 | MAOB (0.46) | ALDH1A1KDM4EHTTCNR2 | |
| SCHEMBL4786806 | 0.81 | ALDH1A1 (0.48) | ALDH1A1HPGDKDM4EGAAHTT | |
| SCHEMBL4787618 | 0.73 | CYP1A2 (0.47) | ALDH1A1HPGDKDM4EGAAMAPT | |
| SCHEMBL4787413 | 0.72 | TP53 (0.51) | ALDH1A1HPGDGAAHTTTP53 | |
| SCHEMBL4784399 | 0.72 | RAB9A (0.38) | ALDH1A1GAA | |
| SCHEMBL17153358 | 0.71 | CYP11B2 (0.46) | ALDH1A1KDM4ETP53MAPTL3MBTL1 | |
| SCHEMBL28487655 | 0.70 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4EGAAHTT | |
| SCHEMBL29411936 | 0.70 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4EGAAHTT | |
| Hydrochloric Acid SCHEMBL8687192 | 0.69 | CCR2 (0.57) | CCR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008111794-A1 | 4-METHYLIMIDAZOL-5-YLCARBONYLGUANIDINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF THE ISCHEMIC HEART DISEASES CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-09-18 | — | — | WO | disclosed |