Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | FPR3 | P25089 | 1/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 2/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.47 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786204 | 0.97 | EPHX2 (0.60) | EPHX2CHRNA7KCNH2HTR7SIRT1 | |
| SCHEMBL4787642 | 0.94 | EPHX2 (0.63) | EPHX2CHRNA7KCNH2HTR3AMCHR1 | |
| SCHEMBL4788178 | 0.92 | EPHX2 (0.58) | EPHX2CHRNA7KCNH2SIRT1HTR3A | |
| SCHEMBL4788021 | 0.91 | EPHX2 (0.64) | EPHX2CHRNA7KCNH2HTR7MCHR1 | |
| SCHEMBL4787450 | 0.90 | EPHX2 (0.63) | EPHX2CHRNA7KCNH2MCHR1MCHR2 | |
| SCHEMBL4786227 | 0.89 | EPHX2 (0.59) | EPHX2CHRNA7KCNH2SIRT1MCHR1 | |
| SCHEMBL4786182 | 0.88 | POLB (0.54) | EPHX2HTR7HTR3AMCHR1MCHR2 | |
| SCHEMBL4788497 | 0.88 | HTR3A (0.55) | EPHX2CHRNA7KCNH2HTR7SIRT1 | |
| SCHEMBL4788976 | 0.84 | POLB (0.54) | EPHX2CHRNA7KCNH2HTR7SIRT1 | |
| SCHEMBL4786193 | 0.83 | EPHX2 (0.56) | EPHX2HTR3AMCHR1MCHR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008122667-A2 | UREYLENE DERIVATIVES | SCHOOL OF PHARMACY (GB) | 2008-10-16 | — | — | WO | disclosed |