Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 3/20 | 0.56 |
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.51 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.51 |
| ▸ | TXK | P42681 | 1/20 | 0.51 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.51 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 3/20 | 0.50 |
| ▸ | CCNC | P24863 | 2/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.45 |
| ▸ | CLK2 | P49760 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4741519 | 0.80 | RIPK2 (0.57) | GAKKDRRIPK2MAPK14ABL1 | |
| SCHEMBL4787800 | 0.79 | CD38 (0.64) | GAKKDRRIPK2MAPK14ABL1 | |
| SCHEMBL4737841 | 0.79 | GAK (0.69) | GAKKDRRIPK2MAPK14ABL1 | |
| SCHEMBL4741884 | 0.76 | GAK (0.60) | GAKKDRRIPK2MAPK14ABL1 | |
| SCHEMBL30050271 | 0.74 | CCNC (0.48) | GAKKDRRIPK2MAPK14ABL1 | |
| SCHEMBL317086 | 0.74 | CCNC (0.48) | GAKKDRRIPK2MAPK14ABL1 | |
| SCHEMBL5929081 | 0.73 | GAK (0.53) | GAKKDRRIPK2MAPK14ABL1 | |
| SCHEMBL29391609 | 0.71 | GAK (0.65) | GAKKDRRIPK2MAPK14ABL1 | |
| SCHEMBL28845692 | 0.69 | FADS1 (0.66) | GAKKDRRIPK2ABL1EPHB6 | |
| SCHEMBL30880706 | 0.69 | GAK (0.80) | GAKKDRRIPK2MAPK14ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089307-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF PAIN, INFLAMMATION AND CANCER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | claimed |
| WO-2008089310-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF OBESITY | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | claimed |
| US-20080200458-A1 | Methods and compositions for the treatment of body composition disorders | LEXICON PHARMACEUTICALS, INC. | 2008-08-21 | — | — | US | disclosed |
| US-20080194557-A1 | Methods and compositions for the treatment of pain, inflammation and cancer | LEXICON PHARMACEUTICALS, INC. | 2008-08-14 | — | — | US | disclosed |
| WO-2008089310-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF OBESITY | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008089307-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF PAIN, INFLAMMATION AND CANCER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194557-A1 | Methods and compositions for the treatment of pain, inflammation and cancer | TNF, IL6, CXCL8 | GAK 2043/4885KDR 1066/4885RIPK2 3512/4885 |
| US-20080200458-A1 | Methods and compositions for the treatment of body composition disorders | CPT1B, CPT1A, SHBG | GAK 3733/4885KDR 4840/4885RIPK2 4828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.