Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 4/20 | 0.69 |
| ▸ | FADS1 | O60427 | 2/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.58 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.58 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.58 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.58 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.58 |
| ▸ | TXK | P42681 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | CCNC | P24863 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.50 |
| ▸ | CD38 | P28907 | 1/20 | 0.47 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28845692 | 0.90 | FADS1 (0.66) | GAKFADS1RIPK2COQ8ANLK | |
| SCHEMBL4787800 | 0.85 | CD38 (0.64) | GAKFADS1RIPK2COQ8ANLK | |
| SCHEMBL4741884 | 0.84 | GAK (0.60) | GAKFADS1RIPK2COQ8ANLK | |
| SCHEMBL4740996 | 0.83 | FADS1 (0.71) | GAKFADS1RIPK2COQ8ANLK | |
| SCHEMBL21121890 | 0.82 | FADS1 (0.59) | GAKFADS1ABL1CA9PTK6 | |
| SCHEMBL29391609 | 0.81 | GAK (0.65) | GAKRIPK2COQ8ANLKEPHB6 | |
| SCHEMBL4741519 | 0.81 | RIPK2 (0.57) | GAKRIPK2COQ8ANLKEPHB6 | |
| SCHEMBL15614056 | 0.81 | FADS1 (0.71) | GAKFADS1RIPK2COQ8ANLK | |
| SCHEMBL4740569 | 0.80 | FADS1 (1.00) | GAKFADS1RIPK2COQ8ANLK | |
| SCHEMBL4787477 | 0.79 | GAK (0.56) | GAKFADS1RIPK2COQ8ANLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089310-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF OBESITY | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | claimed |
| WO-2008089307-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF PAIN, INFLAMMATION AND CANCER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | claimed |
| US-20240216316-A1 | DIHOMO-GAMMA LINOLENIC ACID (DGLA) IS A NOVEL SENOLYTIC | BUCK INST RES AGING (US) | 2024-07-04 | — | — | US | disclosed |
| US-20080200458-A1 | Methods and compositions for the treatment of body composition disorders | LEXICON PHARMACEUTICALS, INC. | 2008-08-21 | — | — | US | disclosed |
| US-20080194557-A1 | Methods and compositions for the treatment of pain, inflammation and cancer | LEXICON PHARMACEUTICALS, INC. | 2008-08-14 | — | — | US | disclosed |
| WO-2008089307-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF PAIN, INFLAMMATION AND CANCER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008089310-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF OBESITY | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194557-A1 | Methods and compositions for the treatment of pain, inflammation and cancer | TNF, IL6, CXCL8 | GAK 2043/4885FADS1 1059/4885RIPK2 3512/4885 |
| US-20240216316-A1 | DIHOMO-GAMMA LINOLENIC ACID (DGLA) IS A NOVEL SENOLYTIC | DAGLA, DAGLB, MGLL | GAK 617/4885FADS1 192/4885RIPK2 2415/4885 |
| US-20080200458-A1 | Methods and compositions for the treatment of body composition disorders | CPT1B, CPT1A, SHBG | GAK 3733/4885FADS1 270/4885RIPK2 4828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.