Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743050 | 0.92 | TSHR (0.44) | SMN1; SMN2LMNAHTTRECQLTSHR | |
| SCHEMBL4743021 | 0.91 | ALDH1A1 (0.42) | SMN1; SMN2LMNAHTTRECQLTSHR | |
| SCHEMBL4788634 | 0.89 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAHTTRECQLTSHR | |
| SCHEMBL4788023 | 0.82 | TSHR (0.43) | LMNARECQLTSHRMAPTPOLB | |
| SCHEMBL4742206 | 0.81 | ALDH1A1 (0.43) | SMN1; SMN2HTTALDH1A1MAPTPOLB | |
| SCHEMBL4746166 | 0.80 | TSHR (0.43) | SMN1; SMN2LMNAHTTRECQLTSHR | |
| SCHEMBL4787528 | 0.80 | ALDH1A1 (0.47) | SMN1; SMN2LMNAHTTRECQLALDH1A1 | |
| SCHEMBL4785277 | 0.78 | KMT2A (0.42) | SMN1; SMN2LMNAHTTRECQLTSHR | |
| SCHEMBL4785121 | 0.77 | TSHR (0.54) | SMN1; SMN2LMNAHTTRECQLTSHR | |
| SCHEMBL4787718 | 0.77 | TSHR (0.41) | SMN1; SMN2LMNAHTTRECQLTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | claimed |