Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786708 | 0.90 | MAPT (0.46) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL4742206 | 0.87 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1MAPTPOLB | |
| SCHEMBL8160491 | 0.83 | ACLY (0.50) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL4743050 | 0.81 | TSHR (0.44) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL4787944 | 0.80 | SMN1; SMN2 (0.48) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL8154008 | 0.78 | MAPT (0.49) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL4787536 | 0.78 | ALDH1A1 (0.55) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL8161152 | 0.78 | TP53 (0.45) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL4785277 | 0.78 | KMT2A (0.42) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL4745397 | 0.77 | KMT2A (0.43) | ALDH1A1KMT2AMEN1MAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | claimed |
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | disclosed |