Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743021 | 0.91 | ALDH1A1 (0.42) | TSHRPOLBKMT2AMEN1LMNA | |
| SCHEMBL4743050 | 0.91 | TSHR (0.44) | TSHRGFERPOLBKMT2AMEN1 | |
| SCHEMBL4786482 | 0.88 | TSHR (0.42) | TSHRGFERPOLBKMT2AMEN1 | |
| SCHEMBL4745397 | 0.86 | KMT2A (0.43) | POLBKMT2AMEN1ALOX15L3MBTL1 | |
| SCHEMBL4746067 | 0.83 | KMT2A (0.46) | POLBKMT2AMEN1LMNAALOX15 | |
| SCHEMBL4787944 | 0.82 | SMN1; SMN2 (0.48) | TSHRPOLBKMT2AMEN1LMNA | |
| SCHEMBL4787200 | 0.81 | TSHR (0.43) | TSHRGFERPOLBKMT2ALMNA | |
| SCHEMBL4787431 | 0.81 | IDO1 (0.47) | TSHRGFERPOLBKMT2AMEN1 | |
| SCHEMBL8161152 | 0.81 | TP53 (0.45) | TSHRPOLBKMT2AMEN1LMNA | |
| SCHEMBL4746166 | 0.80 | TSHR (0.43) | TSHRGFERPOLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | claimed |