Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784226 | 0.94 | KMT2A (0.46) | KMT2AMEN1LMNAALDH1A1POLB | |
| SCHEMBL4786988 | 0.91 | ALDH1A1 (0.46) | KMT2AMEN1LMNAALDH1A1POLB | |
| SCHEMBL4785661 | 0.88 | KMT2A (0.50) | KMT2AMEN1LMNAALDH1A1POLB | |
| SCHEMBL4786353 | 0.83 | ALDH1A1 (0.49) | KMT2AMEN1LMNAALDH1A1POLB | |
| SCHEMBL4788750 | 0.82 | HSD11B1 (0.47) | KMT2AMEN1LMNAALDH1A1POLB | |
| SCHEMBL4745397 | 0.80 | KMT2A (0.43) | KMT2AMEN1ALDH1A1POLBHSD17B10 | |
| SCHEMBL4743050 | 0.78 | TSHR (0.44) | KMT2AMEN1LMNAALDH1A1POLB | |
| SCHEMBL4746067 | 0.78 | KMT2A (0.46) | KMT2AMEN1LMNAALDH1A1POLB | |
| SCHEMBL4787944 | 0.78 | SMN1; SMN2 (0.48) | KMT2AMEN1LMNAALDH1A1POLB | |
| SCHEMBL4787528 | 0.78 | ALDH1A1 (0.47) | KMT2AMEN1LMNAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | claimed |
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | disclosed |