Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786704 | 0.87 | AKR1B10 (0.40) | NTRK1NTRK2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4788527 | 0.79 | MAPK14 (0.42) | GAACASP3LMNATP53MAPT | |
| SCHEMBL4747721 | 0.79 | KDM4C (0.41) | ALDH1A1KDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL5815996 | 0.76 | ALDH1A1 (0.37) | ALDH1A1KDM4EHSD17B10ALOX15NPC1 | |
| SCHEMBL4787999 | 0.75 | MAPT (0.39) | ALDH1A1KDM4EHSD17B10AKR1B10PARP1 | |
| SCHEMBL4751131 | 0.75 | KDM4C (0.38) | ALDH1A1KDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL4747281 | 0.73 | EGFR (0.46) | ALDH1A1HSD17B10GAASMN1; SMN2TP53 | |
| SCHEMBL23958849 | 0.68 | NPC1 (0.56) | NTRK1NTRK2ALDH1A1PKMKDM4E | |
| SCHEMBL4788529 | 0.68 | HTR2A (0.38) | NTRK1NTRK2ALDH1A1PKMKDM4E | |
| SCHEMBL4750216 | 0.67 | GRIA1 (0.40) | NTRK2ALDH1A1KDM4EHSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123755-A1 | A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA | SK CHEMICALS CO., LTD. (KR) | 2008-10-16 | — | — | WO | claimed |
| WO-2008123755-A1 | A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA | SK CHEMICALS CO., LTD. (KR) | 2008-10-16 | — | — | WO | disclosed |