Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786908 | 0.79 | NR1H2 (0.39) | KDM4ETDP1KMT2AMEN1ALDH1A1 | |
| SCHEMBL4786769 | 0.74 | KDM4E (0.46) | KDM4ETDP1HTTKMT2AMEN1 | |
| SCHEMBL4788901 | 0.74 | ALDH1A1 (0.48) | ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL17724355 | 0.64 | CYP2A13 (0.58) | KDM4ETDP1HTTCYP2A13KMT2A | |
| SCHEMBL4787954 | 0.64 | MEN1 (0.39) | KDM4EKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL4213722 | 0.63 | ADRA1A (0.40) | KDM4EHTTALDH1A1GAAADRA1A | |
| SCHEMBL6819440 | 0.63 | ADRA1A (0.40) | KDM4EHTTALDH1A1GAAADRA1A | |
| SCHEMBL7238644 | 0.62 | ADRB1 (0.44) | ADRA1A | |
| SCHEMBL7238635 | 0.62 | ADRB1 (0.44) | ADRA1A | |
| SCHEMBL29605223 | 0.62 | ADRA1A (0.52) | ALDH1A1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |